S-Adenosyl Methionine Prevents Endothelial Dysfunction by Inducing Heme Oxygenase-1 in Vascular Endothelial Cells

• DOI: 10.1007/s10059-013-0210-y
• Publication Date: 2013-09-18T00:50:24Z
• Authors: Sun Young Kim; Seok Woo Hong; Mi-Ok Kim; Hyun-Sik Kim; Jung Eun Jang; Jaechan Leem; In-Sun Park; Ki-Up Lee; Eun Hee Koh
• Keywords: Endothelial Dysfunction

S-adenosyl methionine (SAM) is a key intermediate in the metabolism of sulfur amino acids and major methyl donor cell. Although low plasma level SAM has been associated with atherosclerosis, effect administration on atherosclerosis not known. Endothelial dysfunction an early prerequisite for atherosclerosis. This study was undertaken to investigate possible preventive endothelial molecular mechanism its action. treatment prevented high fat diet (HFD)-fed rats. In cultured human aortic cells, linoleic acid (LA) increased decreased cell apoptosis endoplasmic reticulum stress. Both LA heme oxygenase-1 (HO-1) expression NF-E2-related factor 2-dependent manner. However, knockdown HO-1 reversed only SAM-induced apoptosis. The LA-induced dependent PPARα, whereas induced PPAR-independent These data demonstrate that prevents HFDfed animals by inducing vascular cells. responsible observed prevention We propose may represent new therapeutic strategy