Disparities in burden of disease in patients with rheumatoid arthritis across racial and ethnic groups

• DOI: 10.1007/s10067-024-06869-9
• Publication Date: 2024-01-25T02:02:42Z
• Authors: Jacqueline O’Brien; Sang Hee Park; Taylor Blachley; Maya Marchese; Nicole Middaugh; Keith Wittstock; Leslie R. Harrold
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Brief Report

Abstract To examine racial/ethnic differences in rheumatoid arthritis (RA) disease burden and change clinical outcomes over time. We included CorEvitas Rheumatoid Arthritis Registry patients from two time periods (2013–2015 2018–2020). Clinical Disease Activity Index (CDAI) (as a continuous measure as dichotomous measure) the Health Assessment Questionnaire-Disability (HAQ-DI) were assessed at each visit. Marginal means their corresponding 95% confidence interval (CI) by race/ethnicity estimated for outcome using adjusted mixed effects linear logistic regression models. Overall pairwise tests conducted to detect between groups. Of 9,363 eligible (8,142 White, 527 Black, 545 Hispanic, 149 Asian), most (76%–85%) female. At Visit 1, mean duration ranged 9.8–11.8 years. Estimated CDAI was significantly higher Hispanics compared Whites 1 (11.1 vs. 9.9; P = 0.033) 2 (9.2 8.0, 0.005). activity improved 5-year study period among all groups, though less than Whites. across racial/ethnicity disparities groups functional status did persist time, suggesting that further effort is needed understand drivers of these discrepancies close this gap. Key Points • racial ethnic Disparities