Antibacterial activity of a novel flavonoid, 7-O-butyl naringenin, against methicillin-resistant Staphylococcus aureus (MRSA)

• DOI: 10.1007/s10068-013-0272-9
• Publication Date: 2013-10-17T08:47:37Z
• Authors: Kyoung Ah Lee; Sun-Hee Moon; Joo-Yeon Lee; Kee-Tae Kim; Yong-Sun Park; Hyun-Dong Paik
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

The objective of this study was to evaluate the antibacterial activity of a novel flavonoid, 7-O-butyl naringenin, as well as natural flavonoids (quercetin, naringenin) against methicillin-resistant Staphylococcus aureus (MRSA). 7-O-butyl naringenin showed great anti-MRSA, with a MIC (minimum inhibitory concentration) value of 0.625 mM. The number of cells treated with 25 μM 7-O-butyl naringenin was reduced by 5.2 log CFU/mL compared with the control (DMSO). The result indicated that 7-O-butyl naringenin was more effective than the two natural flavonoids against MRSA, and may have potential as a novel therapeutic agent for MRSA infections.