Abnormality of multimodal evoked potentials in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

• DOI: 10.1007/s10072-020-04351-3
• Publication Date: 2020-03-24T05:33:37Z
• Authors: Edyta Dziadkowiak; Maria Ejma; Malgorzata Wieczorek; Pawel Pec; Krzysztof Slotwiński; Slawomir Budrewicz; Anna Zimny; Magdalena Koszewicz
• Keywords: Central Nervous System; 03 medical and health sciences; 0302 clinical medicine; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Peripheral Nervous System; Evoked Potentials, Visual; Humans; Original Article; Peripheral Nerves; Evoked Potentials; 3. Good health

Abstract Introduction Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, sometimes including the central nervous system. The aim of the study was the assessment of the prevalence of central sensory impairment and its reliance on peripheral nerve damage in patients with CIDP.

Material and methods Multimodal (visual—VEP, brainstem auditory—BAEP, somatosensory—SEP) evoked potentials (EPs) were studied in 24 patients diagnosed with CIDP. The results were compared with neurographic parameters of sensory responses. The control group consisted of 35 healthy volunteers selected with respect to age and sex.

Results Mean latency of most components of EP were considerably prolonged in patients compared with the control group. There were no correlations between the P100 VEP latency and the peripheral sensory parameters. Statistically significant negative correlations were obtained between BAEP and SEP responses and the amplitude and sensory conduction velocity of peripheral nerves. The inter-latencies were also longer.

Conclusions The authors indicated to the possibility of central sensory involvement in patients with CIDP, especially based on the prolonged inter-latency of BAEPs with simultaneously confirmed root affection. The severity of central damage correlates with the degree of peripheral nerve impairment.