Whole blood viscosity is associated with baseline cerebral perfusion in acute ischemic stroke

• DOI: 10.1007/s10072-021-05666-5
• Publication Date: 2021-10-20T17:49:40Z
• Authors: Prajwal Gyawali; Thomas Patrick Li...; Shinya Tomari; Andrew Bivard; Elizabeth Holliday; Mark Parsons; Christopher Levi; Carlos Garcia-Esp...; Neil Spratt
• Keywords: Stroke; Neuroradiology

Whole blood viscosity (WBV) is the intrinsic resistance to flow developed due frictional force between adjacent layers of flowing blood. Elevated WBV an independent risk factor for stroke. Poor microcirculation elevated can prevent adequate perfusion brain and might act as important secondary hypoperfusion in acute ischaemic In present study, we examined association with basal cerebral assessed by CT Confirmed ischemic stroke patients (n = 82) presenting hours were recruited from single centre. Patients underwent baseline multimodal (non-contrast CT, angiography perfusion). Where clinically warranted, also follow-up DWI. was measured duplicate within 2 h after sampling 5-mL EDTA sample. significantly correlated parameters such lesion volume, core volume mismatch ratio; DWI NIHSS. a multivariate linear regression model, predicted ratio adjusting effect occlusion site collateral status. Association (increased ratio) suggest role erythrocyte rheology haemodynamic The findings open new possibilities therapeutic strategies targeting improve