Low prevalence of Blastocystis sp. in active ulcerative colitis patients

• DOI: 10.1007/s10096-015-2312-2
• Publication Date: 2015-02-13T09:28:33Z
• Authors: N. G. Rossen; A. Bart; N. Verhaar; E. van Nood; R. Kootte; P. F. de Groot; G. R. D’Haens; C. Y. Ponsioen; T. van Gool
• Keywords: Blastocystis; Interquartile range; Medical microbiology; Etiology

Ulcerative colitis (UC) is thought to originate from a disbalance in the interplay between gut microbiota and innate adaptive immune system. Apart bacterial microbiota, there might be other organisms, such as parasites or viruses, that could play role aetiology of UC. The primary objective this study was compare prevalence Blastocystis sp. cohort patients with active UC healthy controls. We studied confirmed by endoscopy included randomised prospective trial on faecal transplantation for A subjects who served donors trials were Healthy did not have gastrointestinal symptoms extensively screened infectious diseases screenings questionnaire, extensive serologic assessment viruses stool analysis. Potential parasitic infections diagnosed triple faeces test (TFT). compared groups Chi-square testing. total 168 included, whom 45 had [median age 39.0 years, interquartile range (IQR) 32.5-49.0, 49 % male] 123 (median 27 IQR 22.0-37.0, 54 male). present 40/123 (32.5 %) 6/45 (13.3 (p = 0.014). Infection significantly less frequent