Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

• DOI: 10.1007/s10096-022-04425-4
• Publication Date: 2022-03-17T17:09:03Z
• Authors: Burcu Isler; Berna Özer; Güle Çınar; Abdullah Tarık Aslan; Cansel Vatansever; Caitlin Falconer; İştar Dolapçı; Funda Şimşek; Necla Tülek; Hamiyet Demirkaya; Şirin Menekşe; Halis Akalin; İlker İnanç Balkan; Mehtap Aydın; Elif Tükenmez Tigen; Safiye Koçulu Demir; Mahir Kapmaz; Şiran Keske; Özlem Doğan; Çiğdem Arabacı; Serap Yağcı; Gülşen Hazırolan; Veli Oğuzalp Bakır; Mehmet Gönen; Mark D. Chatfield; Brian Forde; Neşe Saltoğlu; Alpay Azap; Özlem Azap; Murat Akova; David L. Paterson; Füsun Can; Önder Ergönül
• Keywords: Medical microbiology; Carbapenem; Bloodstream infection

A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.