Spectrum and mortality of opportunistic infections among HIV/AIDS patients in southwestern China

• DOI: 10.1007/s10096-022-04528-y
• Publication Date: 2022-11-22T15:03:01Z
• Authors: Sirun Meng; Qiao Tang; Zhiman Xie; Nianning Wu; Yingmei Qin; Rongfeng Chen; Xiaoyu Chen; Xiu Chen; Yueqi Li; Minjuan Shi; Li Ye; Hao Liang; Junjun Jiang; Bo Zhou; Jianyan Lin
• Keywords: China; Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Coinfection; Brief Report; HIV Infections; CD4 Lymphocyte Count; 3. Good health; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Humans; Retrospective Studies

AbstractWe describe the opportunistic infections (OIs) of HIV/AIDS to understand the spectrum, mortality, and frequency of multiple coinfected OIs among HIV/AIDS patients in southern China, where OIs are severe. We carried out a retrospective cohort study of hospitalized HIV-infected individuals at the Fourth People’s Hospital of Nanning, Guangxi, China, from Jan. 2011 to May. 2019. The chi-square test was used to analyze cross-infection; the Kaplan‒Meier analysis was used to compare mortality. A total of 12,612 HIV-infected patients were admitted to this cohort study. Among them, 8982 (71.2%) developed one or more OIs. The overall in-hospital mortality rate was 9.0%. Among the patients, 35.6% coinfected one OI, and 64.4% coinfected more than two OIs simultaneously. Almost half of the patients (60.6%) had CD4 + T-cell counts < 200 cells/μL. Pneumonia (39.8%), tuberculosis (35.3%), and candidiasis (28.8%) were the most common OIs. Coinfected cryptococcal meningitis and dermatitis are the most common combined OIs. The rate of anaemia (17.0%) was highest among those common HIV-associated complications. Multiple OIs are commonly found in hospitalized HIV/AIDS patients in southwestern China, which highlights the need for improved diagnosis and treatment.