Tumor-associated epilepsy in patients with brain metastases: necrosis-to-tumor ratio forecasts postoperative seizure freedom

• DOI: 10.1007/s10143-021-01560-y
• Publication Date: 2021-05-14T14:02:54Z
• Authors: Majd Bahna; Muriel Heimann; Christian Bode; Valeri Borger; Lars Eichhorn; Erdem Güresir; Motaz Hamed; Ulrich Herrlinger; Yon-Dschun Ko; Felix Lehmann; Anna-Laura Potthoff; Alexander Radbruch; Christina Schaub; Rainer Surges; Johannes Weller; Hartmut Vatter; Niklas Schäfer; Matthias Schneider; Patrick Schuss
• Keywords: Brain tumor; Concomitant

Surgical resection is highly effective in the treatment of tumor-related epilepsy (TRE) patients with brain metastases (BM). Nevertheless, some suffer from postoperative persistent which negatively impacts health-related quality life. Therefore, early identification potentially unfavorable seizure outcome after BM important. Patients TRE that had undergone surgery for at authors' institution between 2013 and 2018 were analyzed regard to preoperatively identifiable risk factors outcome. Tumor tissue tumor necrosis ratios assessed volumetrically. According classification International League Against Epilepsy (ILAE), was categorized as favorable (ILAE 1) 2-6) 3 months order avoid potential interference adjuvant cancer treatment. Among all 38 undergoing neurosurgical concomitant TRE, 34 achieved a (90%). Unfavorable significantly associated larger volumes (p = 0.012), midline shift > 7 mm 0.025), necrosis/tumor volume ratio 0.2 0.047). The present study identifies collectable TRE. This might enable preselect vulnerable who benefit accompanying neuro-oncological expertise during further systemical regimes.