Immunogenicity after vaccination of COVID-19 vaccines in patients with cancer: a prospective, single center, observational study

• DOI: 10.1007/s10147-024-02470-x
• Publication Date: 2024-02-21T08:02:58Z
• Authors: Yuki Katsuya; Tatsuya Yoshida; Atsuo Takashima; Kan Yonemori; Akihiro Ohba; Shu Yazaki; Shigehiro Yagishita; Hiroko Nakahama; Osamu Kobayashi; Masatoshi Yanagida; Yasuhiro Irino; Akinobu Hamada; Noboru Yamamoto
• Keywords: Male; 0301 basic medicine; COVID-19 Vaccines; SARS-CoV-2; Vaccination; Infant; COVID-19; Antibodies, Viral; 03 medical and health sciences; Neoplasms; Immunoglobulin G; Humans; Original Article; Female; Prospective Studies

Abstract Background Patients with cancer, particularly those undergoing chemotherapy, are at risk from the low immunogenicity of Coronavirus Disease 19 (COVID-19) vaccines.

Methods This prospective study assessed the seroconversion rate of COVID-19 vaccines among patients with cancer and hospital staff. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein-specific IgG (S-IgG) concentrations were evaluated before the first vaccination, and 1–3 and 4–6 months after the second vaccination. The primary endpoint was the seroconversion rate measured 1–3 months after the second vaccine.

Results In total, 590 patients and 183 healthy hospital staff were analyzed. At 1–3 months after the second vaccination, the S-IgG antibody concentration exceeded the cut-off value (20 BAU/mL) in 96.1% (567/590) of the patients with cancer and 100% (183/183) of the healthy controls (p = 0.0024). At 4–6 months after the second vaccination, the S-IgG antibody concentration exceeded the cut-off value (20 BAU/ml for S-IgG) in 93.1% (461/495) of the patients with cancer and 100% (170/170) of the healthy controls (p < 0.0001). Old age, being male, and low lymphocyte count were related to low SARS-CoV-2 S-IgG levels 1–3 months after the second vaccination among patients, while body mass index, smoking history, and serum albumin level were not. Patients undergoing platinum combination therapy and alkylating agent among cytotoxic drugs, and PARP inhibitor, mTOR inhibitor, and BCR-ABL inhibitor exhibited a low S-IgG antibody concentration compared to the no treatment group.

Conclusions COVID-19 vaccine immunogenicity was reduced among patients with cancer, especially under several treatment regimens.