The cardiothoracic ratio and all-cause and cardiovascular disease mortality in patients undergoing maintenance hemodialysis: results of the MBD-5D study

• DOI: 10.1007/s10157-017-1380-2
• Publication Date: 2017-05-15T05:06:03Z
• Authors: Hiroaki Ogata; Junji Kumasawa; Shingo Fukuma; Masahide Mizobuchi; Eriko Kinugasa; Masafumi Fukagawa; Shunichi Fukuhara; Tadao Akizawa
• Keywords: Quartile

The cardiothoracic ratio (CTR) is a non-invasive left ventricular hypertrophy index. However, whether CTR associates with cardiovascular disease (CVD) and mortality in hemodialysis (HD) populations unclear. Using Mineral Bone disorder Outcomes Study for Japanese CKD Stage 5D Patients (MBD-5D Study) subcohort, 2266 prevalent HD patients (age 62.8 years, female 38.0%, duration 9.4 years) secondary hyperparathyroidism (SHPT) whose baseline had been recorded were selected. We evaluated associations between all-cause death, CVD or composite events patients. was associated significantly various background laboratory characteristics. All-cause CVD-related increased across the quartiles (Q). Adjusted hazard risk (HR) death 1.4 (95% confidential interval, 0.9–2.1) Q2, 1.9 (1.3–2.9) Q3, 2.6 (1.7–4.0) Q4, respectively (Q1 as reference). corresponding adjusted HR 1.8 (0.8–4.2), 3.1 (1.4–6.8), 3.5 (1.6–7.9), that outcome 1.2 (1.0–1.6), 1.7 (1.3–2.2), (1.5–2.3), respectively. Exploratory analysis revealed there relationships age, sex, body mass index, comorbidity of CVD, dialysis duration, dialysate calcium level intact parathyroid hormone, phosphorus, hemoglobin, usage phosphate binder. correlated SHPT.