Rheumatoid arthritis associated with osteopetrosis

• DOI: 10.1007/s10165-009-0208-7
• Publication Date: 2009-08-05T10:12:28Z
• Authors: Yuho Kadono; Sakae Tanaka; Jinju Nishino; Keita Nishimura; Ichiro Nakamura; Tsuyoshi Miyazaki; Hiroshi Takayanagi; Kozo Nakamura
• Keywords: Inflammation; Male; 0301 basic medicine; Middle Aged; Bone and Bones; Arthritis, Rheumatoid; Radiography; 03 medical and health sciences; 0302 clinical medicine; Bone Density; Osteopetrosis; Disease Progression; Humans; Bone Resorption

Osteopetrosis is an inherited disorder characterized by reduced bone resorption. We here report a rare case of osteopetrosis associated with rheumatoid arthritis. The patient was diagnosed as autosomal dominant osteopetrosis type II in his youth and developed rheumatoid arthritis at 42 years of age. In spite of the severe inflammation and rapid progression of cartilage destruction, the progression of bone erosion was slow in this patient.