ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas

• DOI: 10.1007/s10238-009-0040-6
• Publication Date: 2009-03-20T17:38:12Z
• Authors: Regislaine Valéri...; Silvia Aparecida ...; Benedicto Oscar C...; Fernanda Maris Peria; Luis Fernando Tir...; Suely Kazue Nagah...; Suzana Maria Fleu...; Sueli Mieko Oba-S...; Alberto Alain Gabbai; Paulo Andrade Lotufo; Carlos Gilberto C...
• Keywords: Male; 0301 basic medicine; Genotype; PECAM-1; ICAM-1; Astrocytoma; Middle Aged; Intercellular Adhesion Molecule-1; Polymorphism, Single Nucleotide; 3. Good health; Platelet Endothelial Cell Adhesion Molecule-1; 03 medical and health sciences; 669; Humans; Female; Polymorphism

Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.