Comparison of clinical features between patients with and without renal involvement in IgG4-related disease

• DOI: 10.1007/s10238-025-01612-3
• Publication Date: 2025-03-28T10:53:14Z
• Authors: Qixing Yu; Ganyuan He; Zhi Zhao; Jiayi Chen; Qiqi Huang; Wenke Hao; Xiangbin Mi; Wenxue Hu
• Keywords: IgG4-Related Disease; Erythrocyte sedimentation rate; Nomogram; Hematology

The kidney is one of the organs most frequently affected in immunoglobulin G4-related disease (IgG4-RD). Early identification IgG4-RD with renal injury by clinical features a current challenge. There paucity data regarding involvement IgG4-RD. Patients diagnosis and without were included retrospective cohort study. Cox regression analyses used to investigate risk factors for relapse construct nomogram model. From December 2014 February 2022, 54 patients retrospectively enrolled. Renal was observed 55.6% patients. differences age lacrimal gland accumulation statistically significant (P < 0.001, P = 0.034, respectively). Age significantly higher group. Regarding laboratory findings, basophil counts, hemoglobin levels, serum cholinesterase level lower 0.033, 0.006 0.019). Erythrocyte sedimentation rate 0.017). Seven (23.4%) group relapsed during follow-up mean recurrence time 9.86 ± 7.08 months. plays key role patient outcomes. Female, elevated erythrocyte level, complement component 4 are Moreover, an effective model has been developed predict