Positive expression and correlation of chemokine receptor CXCR4 with nodal metastasis and prognosis in colorectal cancer

• DOI: 10.1007/s10330-007-0102-8
• Publication Date: 2007-12-21T07:36:54Z
• Authors: Mengxian Zhang; Kashif Iqbal; Shiying Yu
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Objective Colorectal cancer is one of the leading causes of cancer related deaths, with recurrence and metastasis as the primary reasons for mortality. New evidence has implicated chemokines as the likely cause. We studied the positive expression of CXCR4 chemokine receptors in colorectal carcinoma and investigated its correlations to clinicpathological characteristics and prognosis.