Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla

• DOI: 10.1007/s10334-016-0526-7
• Publication Date: 2016-02-09T09:10:03Z
• Authors: Yan Li; Angela Jakary; Erin Gillung; Stuart Eisendrath; Sarah J. Nelson; Pratik Mukherjee; Tracy Luks
• Keywords: Mindfulness-based cognitive therapy; Echo (communications protocol)

Our aim was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, assess changes metabolites after they completed an 8-week course of mindfulness-based cognitive therapy (MBCT), exam the correlation depression severity. Sixteen MDD ten age- gender-matched controls were studied using 3D short echo-time (20 ms) magnetic resonance spectroscopic imaging (MRSI) at 7 Tesla. Relative ratios estimated five regions interest corresponding insula, anterior cingulate cortex (ACC), caudate, putamen, thalamus. In all cases, MBCT reduced severity depression. The ratio total choline-containing compounds/total creatine (tCr) right caudate significantly increased compared that while N-acetyl aspartate (NAA)/tCr left ACC, myo-inositol/tCr glutathione/tCr putamen decreased. At baseline, negatively correlated my-inositol/tCr insula putamen. improvement associated NAA/tCr ACC. This study has successfully evaluated regional for who received treatment Tesla MRSI.