Semi-automated software to measure luminal and stromal areas of choroid in optical coherence tomographic images

• DOI: 10.1007/s10384-017-0558-1
• Publication Date: 2017-12-21T15:11:23Z
• Authors: Shozo Sonoda; Taiji Sakamoto; Naoko Kakiuchi; Hideki Shiihara; Tomonori Sakoguchi; Masatoshi Tomita; Takehiro Yamashita; Eisuke Uchino
• Keywords: Adult; Male; Fovea Centralis; Choroid; Reproducibility of Results; Middle Aged; Healthy Volunteers; Young Adult; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; ROC Curve; Image Processing, Computer-Assisted; Humans; Female; Prospective Studies; Software; Tomography, Optical Coherence

To determine the capabilities of "EyeGround" software in measuring the choroidal cross sectional areas in optical coherence tomographic (OCT) images.Cross sectional, prospective study.The cross-sectional area of the subfoveal choroid within a 1500 µm diameter circle centered on the fovea was measured both with and without using the EyeGround software in the OCT images. The differences between the evaluation times and the results of the measurements were compared. The inter-rater, intra-rater, inter-method agreements were determined.Fifty-one eyes of 51 healthy subjects were studied: 24 men and 27 women with an average age of 35.0 ± 8.8 years. The time for analyzing a single image was significantly shorter with the software at 3.2±1.1 min than without the software at 12.1±5.1 min (P <0.001). The inter-method correlation efficient for the measurements of the whole choroid was high [0.989, 95% CI (0.981-0.994)]. With the software, the inter-rater correlation efficient was significantly high [0.997, 95% CI (0.995-0.999)], and the intra-rater correlation efficient was also significantly high [0.999, 95% CI (0.999-1.0)].The EyeGround software can measure the choroidal area in the OCT cross sectional images with good reproducibility and in a significantly shorter times. It can be a valuable tool for analyzing the choroid.