Posterior subtenon infusion of triamcinolone acetonide as adjunctive treatment to panretinal photocoagulation using pattern scan laser for diabetic retinopathy

• DOI: 10.1007/s10384-018-0628-z
• Publication Date: 2018-10-17T09:29:52Z
• Authors: Yutaka Yamada; Yoshihiro Takamura; Takehiro Matsumura; Masakazu Morioka; Makoto Gozawa; Masaru Inatani
• Keywords: Male; Diabetic Retinopathy; Laser Coagulation; Tenon Capsule; Middle Aged; Triamcinolone Acetonide; Retina; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Prospective Studies; Injections, Intraocular; Glucocorticoids; Tomography, Optical Coherence; Aged; Follow-Up Studies; Retrospective Studies

To estimate the effect of sub-Tenon's capsule triamcinolone acetonide injection (STTA) combined with panretinal photocoagulation (PRP) using pattern scan laser (PSL) for high risk non-proliferative diabetic retinopathy (NPDR), in terms of the inflammation and the progression of diabetic macular edema (DME).Retrospective comparative analysis.NPDR patients who underwent PRP using PSL with (STTA+PSL group, n=24) or without (PSL group, n=19) pretreatment of STTA were enrolled. We measured anterior flare intensity (AFI) and central retinal thickness (CRT) at day of STTA (day 0), and at 1, 3, 7, 11 and 15 weeks.The CRT of the STTA+PSL group was significantly lower than that of the PSL group at 7 (308.15±69.16 μm versus 340.21±77.91 μm, p = 0.04), 11 (283.8±60.75 μm versus 335.7±67.70 μm, p = 0.01) and 15 weeks (281.13±35.29 μm versus 316.58±54.89 μm, p = 0.02). AFI levels in the STTA+PSL group were significantly lower than those in the PSL group at 11 (10.47±3.40 versus 15.85±8.38, p = 0.007) and 15 weeks (11.38±3.31 versus 14.37±3.85, p = 0.009). The significant improvement in CRT from baseline was noticed through the observational periods in STTA+PSL group, but not in the PSL group.Pretreatment of STTA has the potential to not only prevent the worsening of DME, but also reduce the CRT and AFI of eyes with NPDR after PRP using PSL.