Pressure and Distortion Regulate Human Mesenchymal Stem Cell Gene Expression

• DOI: 10.1007/s10439-008-9629-2
• Publication Date: 2009-01-05T23:05:01Z
• Authors: Anne K. Haudenschild; Adam H. Hsieh; Sunil Kapila; Jeffrey C. Lotz
• Keywords: Mechanotransduction; Chondrogenesis; Tension (geology); mechanobiology

While the concept that physical forces such as tension and compression are involved in mature tissue modeling is widely accepted, role of these specific types mechanical loading differentiation maturation uncommitted cell like human mesenchymal stem cells (hMSCs) currently unknown. We observed hMSCs have fundamental ability to distinguish between dynamic tensile compressive by regulating distinct gene expression patterns differences can be related conformational changes shape volume. Dynamic was found regulate both fibroblastic osteogenic associated genes while up-regulated with chondrogenesis. Identifying mechanotransduction different modes hMSC may greatly enhance rationally design regeneration systems restore proper function.