A Relation Between Near-Wall Particle-Hemodynamics and Onset of Thrombus Formation in Abdominal Aortic Aneurysms

• DOI: 10.1007/s10439-011-0285-6
• Publication Date: 2011-03-05T09:55:36Z
• Authors: C. Basciano; C. Kleinstreuer; S. Hyun; E. A. Finol
• Keywords: Blood Platelets; 0206 medical engineering; Models, Cardiovascular; Thrombosis; 02 engineering and technology; 03 medical and health sciences; 0302 clinical medicine; Leukocytes; Animals; Humans; Computer Simulation; Aorta, Abdominal; Shear Strength; Aortic Aneurysm, Abdominal

A novel computational particle-hemodynamics analysis of key criteria for the onset of an intraluminal thrombus (ILT) in a patient-specific abdominal aortic aneurysm (AAA) is presented. The focus is on enhanced platelet and white blood cell residence times as well as their elevated surface-shear loads in near-wall regions of the AAA sac. The generalized results support the hypothesis that a patient's AAA geometry and associated particle-hemodynamics have the potential to entrap activated blood particles, which will play a role in the onset of ILT. Although the ILT history of only a single patient was considered, the modeling and simulation methodology provided allow for the development of an efficient computational tool to predict the onset of ILT formation in complex patient-specific cases.