LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis

• DOI: 10.1007/s10495-022-01730-3
• Publication Date: 2022-05-26T16:05:23Z
• Authors: Jing Liu; Xiaozhou Li; Jurong Yang; Dongshan Zhang
• Keywords: Ischemic injury

Abstract Although previous studies have revealed that long noncoding RNAs (lncRNAs) regulate the progression of ischemic acute kidney injury (AKI), exact role and mechanism lncRNA ENSMUST_147219 in AKI are not clear. In present study, was induced by vitro vivo. Functionally, mediated apoptosis mouse proximal tubule‐derived cell line (BUMPT). Mechanistically, sponged microRNA (miR)-221-5p to upregulate expression interferon regulatory factor 6 (IRF6) drive apoptosis. Finally, knockdown markedly attenuated targeting miR-221-5p/IRF6 axis. Collectively, our data demonstrated promoted development regulating pathway, which could be considered a new therapeutic target for AKI.