Lanthanum Potentiates GABA-Activated Currents in Rat Pyramidal Neurons of CA1 Hippocampal Field
Pyramidal Cells
Electric Conductivity
Drug Synergism
Rats, Inbred Strains
Hippocampus
Rats
03 medical and health sciences
0302 clinical medicine
Lanthanum
Animals
GABA-A Receptor Agonists
Cells, Cultured
gamma-Aminobutyric Acid
DOI:
10.1007/s10517-005-0503-z
Publication Date:
2005-12-09T08:38:07Z
AUTHORS (1)
ABSTRACT
In CA1 hippocampal pyramidal neurons, lanthanum ions increased the amplitude of GABA-activated currents and shifted the dose-dependence curve to the left, which attests to increased affinity of GABAA-receptors to GABA. The data made it possible to compare the sensitivity GABAA-receptors of pyramidal neurons and similar receptors of other cells to GABA and lanthanum.
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