Tissue availability of afobazole and its major metabolites in rats

• DOI: 10.1007/s10517-007-0189-5
• Publication Date: 2007-10-01T06:51:22Z
• Authors: A. O. Viglinskaya; G. B. Kolyvanov; A. A. Litvin; O. Yu. Kravtsova; V. P. Zherdev; S. B. Seredenin
• Keywords: 0303 health sciences; Morpholines; Biological Availability; Mass Spectrometry; Rats; 3. Good health; 03 medical and health sciences; Anti-Anxiety Agents; Area Under Curve; Animals; Benzimidazoles; Spectrophotometry, Ultraviolet; Chromatography, Liquid

Intraperitoneally injected afobazole and its major metabolites are intensively distributed in highly vascularized tissues of rats, including the liver, spleen, and kidneys; the content of these compounds in moderately and poorly vascularized tissues (muscles and mesentery) is much lower. Afobazole and its metabolites possess intermediate ability to penetrate into the brain.