Effect of Glyprolines PGP, GP, and PG on Homeostasis of Gastric Mucosa in Rats with Experimental Ethanol-Induced Gastric Ulcers

• DOI: 10.1007/s10517-010-1028-7
• Publication Date: 2010-10-27T01:27:49Z
• Authors: T. M. Falalyeyeva; G. E. Samonina; T. V. Beregovaya; L. A. Andreeva; E. A. Dvorshchenko
• Keywords: Male; 0303 health sciences; Ethanol; Proline; Rats; 3. Good health; 03 medical and health sciences; Gastric Mucosa; Animals; Homeostasis; Lipid Peroxidation; Stomach Ulcer; Rats, Wistar

The decrease in the severity of erosions and ulcer lesions after preventive treatment with PGP or PG correlated with a decrease in the content of lipid peroxidation products to a control level. Activities of SOD and catalase also returned to control values. GP produced the weakest effect on pro- and antioxidant state of the gastric mucosa. We concluded that the pronounced preventive effect of PGP and PG on the development of ethanol-induced erosions and ulcer lesions is largely determined by their antioxidant properties. Glyprolines can be considered as a promising means for prevention and treatment of stomach and duodenal ulcers.