In Vitro Study of Neuroprotective Properties of GK-2, a New Original Nerve Growth Factor Mimetic

• DOI: 10.1007/s10517-011-1202-6
• Publication Date: 2011-03-24T05:47:03Z
• Authors: T. A. Antipova; T. A. Gudasheva; S. B. Seredenin
• Keywords: Neurotoxin; MPTP

New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10(-9)M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H(2)O(2)and glutamate. GK-2 in a concentration of 10(-8)M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.