A Model of Hyperhomocysteine-Induced Endothelial Dysfunction in Rats

• DOI: 10.1007/s10517-011-1491-9
• Publication Date: 2011-12-09T06:08:34Z
• Authors: M. V. Korokin; M. V. Pokrovskiy; O. O. Novikov; O. S. Gudyrev; V. V. Gureev; T. A. Denisyuk; L. V. Korokina; L. M. Danilenko; V. A. Ragulina; E. A. Konovalova; A. S. Belous
• Keywords: Endothelial Dysfunction; Rat model

Intragastric methionine (3 g/kg daily for 7 days) elevates homocysteine concentration and increases the endothelial dysfunction coefficient. This protocol of methionine treatment is an adequate model of hyperhomocysteine-induced endothelial dysfunction and can be used for studies of the endothelio- and cardioprotective effects of drugs.