Neuroprotective Effects of Individual or Combined Exposure to Hypoxia and Hypercapnia in the Experiment

• DOI: 10.1007/s10517-013-2145-x
• Publication Date: 2013-07-18T01:59:59Z
• Authors: P. P. Tregub; V. P. Kulikov; A. G. Bespalov; A. Ju. Vvedensky; I. S. Osipov
• Keywords: 0301 basic medicine; Carbon Dioxide; Statistics, Nonparametric; Rats; 3. Good health; Hypercapnia; Oxygen; 03 medical and health sciences; Neuroprotective Agents; 0302 clinical medicine; Ischemia; Administration, Inhalation; Animals; Hypoxia; Psychomotor Performance

We studied the effects of hypoxic, hypercapnic, and hypercapnic-hypoxic exposures on brain tolerance to ischemia. All respiratory training modes had a neuroprotective effect, but the most pronounced effect was observed after exposure to hypercapnic hypoxia. Experimental stroke in rats preliminary exposed to hypercapnic hypoxia was associated with minimal neurological deficit and motor coordination disturbances in comparison with training modes.