Possibility of Usage of Aminostigmine Structural Analogue for the Treatment of Toxic Cognitive Disorders

• DOI: 10.1007/s10517-014-2347-x
• Publication Date: 2014-01-15T01:15:25Z
• Authors: I. V. Fateev; S. N. Subbotina; A. F. Kurpyakova; M. A. Tyunin
• Keywords: Lethal Dose 50; Male; 03 medical and health sciences; 0302 clinical medicine; Animals; Carbamates; Cognition Disorders; Pyridostigmine Bromide; Rats; 3. Good health

We studied the effects of 2-(hexyl(methyl)amino)methyl)pyridyl-3-dimethyl carbamate (OPDC), a structural analogue of aminostigmine oxalate, on memory formation in rats with toxic scopolamine-induced amnesia. It was shown that OPDC in non-toxic doses ((1)/215 LD50) has significant anti-amnesic action. Ipidacrine and galantamine in the doses similar to toxic doses ((1)/17 and (1)/6 of LD50, respectively) induced the retention of memory trace. Administration of aminostigmine ((1)/11 of LD50) induced unstable anti-amnesic effect in the model of scopolamine-induced amnesia.