Role of NF-κB-Dependent Signaling and p38 MAPK Signaling Pathway in the Control of Hemopoiesis during Cytostatic Administration

• DOI: 10.1007/s10517-014-2485-1
• Publication Date: 2014-06-10T17:31:44Z
• Authors: A. M. Dygai; V. V. Zhdanov; G. N. Zyuz’kov; E. V. Udut; L. A. Miroshnichenko; E. V. Simanina; A. V. Chaikovskii; L. A. Stavrova; M. G. Danilets
• Keywords: Male; 0303 health sciences; Primary Cell Culture; Imidazoles; NF-kappa B; Bone Marrow Cells; Cell Differentiation; Myeloablative Agonists; Gold Sodium Thiomalate; Hematopoiesis; Mice; 03 medical and health sciences; Erythroid Cells; Gene Expression Regulation; Granulocyte Colony-Stimulating Factor; Mice, Inbred CBA; Animals; Enzyme Inhibitors; Cyclophosphamide; Injections, Intraperitoneal; Cell Proliferation; Granulocytes

The study examines the role of signal pathways in triggering the compensatory reactions in the blood system in response to the cytostatic administration. In vitro experiments elucidated the involvement of protein kinase p38 in the synthesis of granulocytic CSF by cells of hemopoietic microenvironment. The important role of the transcriptional factor NF-κB and protein kinase p38 in limitation of the processes of maturation of the hemopoietic precursors was demonstrated.