Role of Receptors to Fibroblast Growth Factor (FGF) on Mesenchymal Precursor Cells in the Realization of Regenerative Effects of Alkaloid Songorine

• DOI: 10.1007/s10517-014-2511-3
• Publication Date: 2014-06-10T23:13:28Z
• Authors: G. N. Zyuz’kov; A. V. Chaikovskii; A. A. Ligacheva; V. V. Zhdanov; E. V. Udut; M. G. Danilets; L. A. Miroshnichenko; E. V. Simanina; N. I. Suslov; E. A. Losev; E. S. Trofimova; T. N. Povet’eva; Yu. V. Nesterova; T. I. Fomina; M. Yu. Minakova; A. M. Dygai
• Keywords: 0301 basic medicine; Wound Healing; Aconitum; Gene Expression; Mesenchymal Stem Cells; Wounds, Nonpenetrating; Receptors, Fibroblast Growth Factor; Antibodies; Fibroblast Growth Factors; Mice; 03 medical and health sciences; Alkaloids; Animals, Outbred Strains; Animals; Cells, Cultured; Signal Transduction; Skin

We studied the mechanisms of regenerative (wound healing) effects of songorine associated with functional activation of mesenchymal progenitor cells. The key role of FGF receptors on these progenitor cells in the stimulation of realization of their growth potential under the effect of the alkaloid was demonstrated. Under in vitro conditions, the antibodies to FGF receptor abolished the songorine-induced increase in the number of fibroblast colony-forming units in bone marrow cell culture. The intensity of differentiation of mesenchymal precursors remained unchanged.