Participation of Signaling Cascades in the Regulation of Erythropoiesis under Conditions of Cytostatic Treatment

• DOI: 10.1007/s10517-015-2747-6
• Publication Date: 2015-01-11T21:03:48Z
• Authors: A. M. Dygai; V. V. Zhdanov; L. A. Miroshnichenko; E. V. Udut; G. N. Zyuz’kov; E. V. Simanina; A. V. Chaikovskii; L. A. Stavrova; E. S. Trofimova; Ya. V. Burmina
• Keywords: 0301 basic medicine; Antimetabolites, Antineoplastic; Mice; 03 medical and health sciences; NF-kappa B; Animals; Erythropoiesis; Fluorouracil; Cytostatic Agents; Erythropoietin; p38 Mitogen-Activated Protein Kinases; 3. Good health

We studied the role of signaling pathways in the regulation of erythropoiesis against the background of myelosuppression caused by administration of 5-fluorouracil. The important role of cyclic AMP in the maturation of erythroid progenitors after cytostatic treatment was demonstrated. The secretory activity of myelokaryocytes during the period of erythroid hemopoiesis recovery is mainly regulated via the p38 MAPK signaling pathway; non-erythropoietin factors are involved in the formation of erythropoietic activity of adherent cells of the microenvironment.