Transplantation of Simian Mesenchymal Stem Cells to Baboons with Experimentally Induced Myocardial Infarction

• DOI: 10.1007/s10517-016-3223-7
• Publication Date: 2016-02-23T19:34:13Z
• Authors: V. Z. Agrba; V. A. Porkhanov; D. D. Karal-ogly; A. V. Leontyuk; A. L. Kovalenko; I. Yu. Sholin; T. E. Gvozdik; I. E. Ignatova; A. A. Agumava; Yu. P. Chuguev; I. A. Gvaramiya; B. A. Lapin
• Keywords: Arteriogenesis

Culture of mesenchymal stem cells isolated from the bone marrow of primates by their characteristics met the requirements of stem cells. It was shown that transplantation of allogeneic mesenchymal stem cells (2 million cells per 1 kg body weight) immediately after ligation of the left anterior descending coronary artery between the middle and upper thirds led to neovascularization and capillarization of the ischemic myocardium.