Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia

• DOI: 10.1007/s10517-016-3481-4
• Publication Date: 2016-10-05T04:08:12Z
• Authors: P. P. Tregub; N. A. Malinovskaya; V. P. Kulikov; A. B. Salmina; M. E. Nagibaeva; A. S. Zabrodina; G. E. Gertsog; S. K. Antonova
• Keywords: Cerebral Cortex; Male; 0301 basic medicine; Apoptosis; Protective Factors; Brain Ischemia; 3. Good health; Hypercapnia; 03 medical and health sciences; 0302 clinical medicine; Animals; Rats, Wistar; Hypoxia, Brain; Ischemic Preconditioning

We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.