Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis

• DOI: 10.1007/s10517-017-3811-1
• Publication Date: 2017-07-25T01:54:05Z
• Authors: I. I. Zamorskii; T. S. Shchudrova; N. S. Lin’kova; T. E. Nichik; V. Kh. Khavinson
• Keywords: Azotemia; Oliguria; Renal Injury

EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats. The nephroprotective effect of EDL peptide manifested in prevention of oliguria and retention azotemia, a decrease in proteinuria and sodium excretion, prevention of critical decrease in activities of antioxidant enzymes, suppression of LPO, and normalization of energy supply to kidneys cells. Our findings confirm the prospects of further studies of the nephroprotective properties of peptide EDL in various pathologies of the kidneys.