Expression of Galectins-1 and Galectin-3 in Stomach and Colorectal Cancer with Tissue Eosinophilia

• DOI: 10.1007/s10517-018-4142-6
• Publication Date: 2018-06-20T06:01:03Z
• Authors: Yu. V. Kolobovnikova; A. I. Dmitrieva; K. I. Yankovich; O. A. Vasil’eva; I. L. Purlik; V. S. Poletika; V. V. Novitskii; O. I. Urazova
• Keywords: Galectin; Galectin-3; Stomach cancer; Infiltration (HVAC); Gastrointestinal cancer

We analyzed the expression of galectin-1 and galectin-3 in tumor tissue in stomach and colorectal cancer with and without tissue eosinophilia. Low expression of galectin-3 was detected in all patients with malignant gastrointestinal tumors irrespective of the presence of eosinophilia. Low expression of galectin-1 was detected only in patients with gastrointestinal cancer associated with eosinophilia. Association of galectin-1 expression with eosinophilic infiltration of the tumor tissue in stomach and colorectal cancer was detected.