Influence of Interleukin-2 and Brain-Derived Neurotrophic Factor (BDNF) on the Size of Myocardial Infarction in Rats with Systemic Inflammatory Response

• DOI: 10.1007/s10517-023-05838-7
• Publication Date: 2023-07-19T02:01:50Z
• Authors: I. Yu. Burovenko; D. L. Sonin; O. V. Borshcheva; M. S. Istomina; E. A. Zaitseva; E. S. Protsak; V. Yu. Borshchev; Yu. Yu. Borshchev; M. M. Galagudza
• Keywords: Tumor Necrosis Factor-alpha; Brain-Derived Neurotrophic Factor; Myocardial Infarction; Animals; Interleukin-2; Cytokines; Systemic Inflammatory Response Syndrome; Rats

We studied the influence of recombinant IL-2 and brain-derived neurotrophic factor (BDNF) on the size of the myocardial necrosis zone of rats with systemic inflammatory response syndrome (SIRS). A significant increase in the necrosis zone and the levels of proinflammatory cytokines was revealed in animals with SIRS in comparison with the control. The administration of IL-2 to animals with SIRS significantly reduced the size of the necrosis zone, which was paralleled by a pronounced increase in IL-2 and BDNF in comparison with the corresponding parameters in rats with SIRS that did not receive IL-2. Administration of BDNF to animals with SIRS was followed by normalization of TNFα and IL-1α levels, but did not lead to a decrease in the size of the necrosis zone.