Cuproptosis-Related Gene FDX1 Suppresses the Growth and Progression of Colorectal Cancer by Retarding EMT Progress

• DOI: 10.1007/s10528-024-10784-8
• Publication Date: 2024-03-23T14:01:31Z
• Authors: Chao Wang; Jingjing Guo; Yun Zhang; Shusheng Zhou; Bing Jiang
• Keywords: CDH1; Tumor progression

Abstract Colorectal cancer (CRC) is a usual and kind of lethiferous cancer. Cuproptosis-related gene ferredoxin 1 (FDX1) has been discovered to act as suppressor, thereby suppressing some cancers’ progression. But, the regulatory functions FDX1 in CRC progression keep vague. In this work, at first, through TCGA database, it was revealed that exhibited lower expression COAD (colon adenocarcinoma) tissues, patients with had worse prognosis. Furthermore, verified be down-regulated tissues ( n = 30) cells. It further uncovered positively correlated CDH1 TJP1 (epithelial marker), negatively CDH2, TWIST1, FN1 (stromal suggesting closely associated epithelial–mesenchymal transition (EMT) progress. Next, demonstrated overexpression suppressed cell viability, invasion, migration CRC. retarded EMT progress Lastly, rescue assays, inhibited mediated by rescued EGF (EMT inducer) treatment. At last, tumor growth metastasis were relieved after overexpression, but these changes reversed conclusion, inhibiting This discovery hinted may an effective candidate for