MicroRNA-1284 inhibits proliferation and induces apoptosis in SGC-7901 human gastric cancer cells

• DOI: 10.1007/s10529-016-2213-1
• Publication Date: 2016-09-15T08:36:08Z
• Authors: Mingwei Huang; Liucheng Wu; Shanshan Luo; Haiquan Qin; Yang Yang; Jiansi Chen; Zhao Li; Yuzhou Qin
• Keywords: Gene Expression Regulation, Neoplastic; 0301 basic medicine; MicroRNAs; 0303 health sciences; 03 medical and health sciences; Caspase 3; Stomach Neoplasms; Cell Line, Tumor; Humans; Apoptosis; Cell Proliferation; 3. Good health

To explore the functional effects of miR-1284 on gastric cancer cells.Overexpression of miR-1284 significantly reduced SGC-7901 cell proliferation, but improved apoptosis. However, miR-1284 suppression displayed the inversed impacts. Furthermore, the protein levels of p27, Bax, procaspase-3 and active caspase-3 were up-regulated by miR-1284 overexpression, but were down-regulated by miR-1284 suppression. The level of Bcl-2 was down-regulated by miR-1284 overexpression, while it was up-regulated by miR-1284 suppression. The level of p21 was unaffected.These results suggest that miR-1284 overexpression might be a suppressor for gastric cancer via controlling of cell proliferation and apoptosis.