IgM monoclonal component associated with type I Gaucher disease resolved after enzyme replacement therapy: A case report

0301 basic medicine Gaucher Disease Antibodies, Monoclonal Monoclonal Gammopathy of Undetermined Significance Recombinant Proteins 3. Good health 03 medical and health sciences Immunoglobulin M Glucosylceramidase Humans Enzyme Replacement Therapy Female Aged
DOI: 10.1007/s10545-009-1207-8 Publication Date: 2009-06-26T19:42:57Z
ABSTRACT
SummaryThe frequency of monoclonal gammopathy of undetermined significance (MGUS) is higher in patients with type I Gaucher disease (GD I) than in the general population. Although enzyme replacement therapy is effective in the control of the disease, its effect on MGUS is still controversial. We present the case of a 65‐year‐old woman with extensive GD I associated with IgM MGUS, in whom enzyme replacement therapy succeeded in eradicating the monoclonal component. This observation further supports the idea that enzyme replacement therapy decreases the chronic antigenic stimulation responsible for gammopathies in Gaucher disease.
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