IgM monoclonal component associated with type I Gaucher disease resolved after enzyme replacement therapy: A case report
0301 basic medicine
Gaucher Disease
Antibodies, Monoclonal
Monoclonal Gammopathy of Undetermined Significance
Recombinant Proteins
3. Good health
03 medical and health sciences
Immunoglobulin M
Glucosylceramidase
Humans
Enzyme Replacement Therapy
Female
Aged
DOI:
10.1007/s10545-009-1207-8
Publication Date:
2009-06-26T19:42:57Z
AUTHORS (7)
ABSTRACT
SummaryThe frequency of monoclonal gammopathy of undetermined significance (MGUS) is higher in patients with type I Gaucher disease (GD I) than in the general population. Although enzyme replacement therapy is effective in the control of the disease, its effect on MGUS is still controversial. We present the case of a 65‐year‐old woman with extensive GD I associated with IgM MGUS, in whom enzyme replacement therapy succeeded in eradicating the monoclonal component. This observation further supports the idea that enzyme replacement therapy decreases the chronic antigenic stimulation responsible for gammopathies in Gaucher disease.
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