Functional Connectivity Lateralisation Shift of Resting State Networks is Linked to Visuospatial Memory and White Matter Microstructure in Relapsing–Remitting Multiple Sclerosis

• DOI: 10.1007/s10548-021-00881-x
• Publication Date: 2021-11-22T16:06:08Z
• Authors: Dániel Veréb; Márton Attila Kovács; Krisztián Kocsis; Eszter Tóth; Bence Bozsik; András Király; Bálint Kincses; Péter Faragó; Zsanett Fricska-Nagy; Krisztina Bencsik; Péter Klivényi; Zsigmond Tamás Ki...; Nikoletta Szabó
• Keywords: Intraparietal sulcus; Angular gyrus

Abstract Laterality patterns of resting state networks (RSN) change in various neuropsychiatric conditions. Multiple sclerosis (MS) causes neuro-cognitive symptoms involving dysfunctional large-scale brain networks. Yet, whether healthy laterality RSNs are maintained MS and altered explain disease has not been explicitly investigated. We analysed functional MRI diffusion tensor imaging data from 24 relapsing–remitting patients 25 participants. performed group-level independent component analysis used dual regression to estimate individual versions well-established RSNs. Voxelwise indices were calculated for each RSN. Group differences assessed via a general linear model-based approach. The relationship between white matter microstructural asymmetry was using Tract-Based Spatial Statistics. Spearman’s correlation Brief International Cognitive Assessment Sclerosis scores. Functional the dorsal attention network showed significant leftward shift group posterior intraparietal sulcus (p < 0.033). Default-mode angular gyrus 0.005). Diminished associated with increased fractional anisotropy superior longitudinal fasciculus 0.02). In default-mode network, higher BVMT-R scores (R = − 0.52, p 0.023). Our results confirm previous descriptions RSN dysfunction show that connectivity lateralisation might contibute cognitive performance structural remodellation even mild clinical symptoms.