The effect of chemotherapy on subjective cognitive function in younger early-stage breast cancer survivors treated with chemotherapy compared to older patients

• DOI: 10.1007/s10549-019-05149-4
• Publication Date: 2019-02-11T21:16:03Z
• Authors: M. L. Gregorowitsch; A. Ghedri; D. A. Young-Afat; R. Bijlsma; I. O. Baas; C. van Schaik-van...; M. J. Agterof; E. Göker; D. ten Bokkel Hui...; H. J. G. D. van d...; H. M. Verkooijen
• Keywords: Depression

To evaluate the impact of chemotherapy on subjective cognitive functioning according to age in a large cohort breast cancer patients.Within UMBRELLA cohort, 715 patients with early-stage primary invasive (T1-3N0-1M0) were selected. Subjective function was assessed by means EORTC QLQ-C30 up 24 months and compared between treated without chemotherapy, for three different strata (355 < 55 years, 240 aged 55-65 120 > 65 years). Differences non-chemotherapy at time points linear mixed-effect models correcting age, tumor stage, educational level, endocrine therapy, anxiety, depression.In total, 979 from included, which (73%) responded baseline least one follow-up questionnaire. Questionnaire response rates ranged 92 70%. The proportion decreased age: 64% (n = 277) 45% 107) 23% 27) years. Chemotherapy associated reduced functioning. most pronounced followed those In youngest groups, had significantly lower months. women over comparable chemotherapy.This study confirms that is impaired self-reported patients, effect persists 2 years after diagnosis. first younger especially under age.