Diagnostic value of core needle biopsy for determining HER2 status in breast cancer, especially in the HER2-low population

• DOI: 10.1007/s10549-022-06781-3
• Publication Date: 2022-11-08T06:02:36Z
• Authors: Ruixian Chen; Yana Qi; Ya Huang; Weijing Liu; Ruoning Yang; Xin Zhao; Yunhao Wu; Qintong Li; Zhu Wang; Xin Sun; Bing Wei; Jie Chen
• Keywords: Concordance

The status of human epidermal growth factor receptor 2 (HER2) is important for treatment decision-making breast cancer and was commonly determined by core needle biopsy (CNB). concordance CNB with surgical excision (SEB) has been verified, but remain unclear according to the newly developed classification HER2 status. Our study aimed re-evaluate diagnostic value determining in cancer, especially HER2-low population.Eligible patients West China Hospital between January 1, 2007 December 31, 2021 were enrolled consecutively data extracted from Information System. agreement SEB calculated rate κ statistics, as well sensitivity, specificity, positive, negative predictive values (PPV & NPV). Logistic models used explore potential factors associated discordance both tests.Of 1829 eligible patients, 1097 (60.0%) 1358 (74.2%) consistent pathological clinical classifications, respectively, being 0.46 (0.43-0.49) 0.57 (0.53-0.60). sensitivity (50.9%-52.7%) PPV (50.5%-55.2%) low among IHC 1+ 2+/ISH - subgroups classifications; however, it showed highest (77.5%) lowest specificity (73.9%) population classifications. Advanced N stages might be a stable indicator tests.The limited population.