Intravascular ultrasound assessment of the effect of laser energy on the arterial wall during the treatment of femoro-popliteal lesions: a CliRpath excimer laser system to enlarge lumen openings (CELLO) registry study

• DOI: 10.1007/s10554-017-1248-2
• Publication Date: 2017-09-26T08:34:38Z
• Authors: Kayode O. Kuku; Hector M. Garcia-...; Edward Koifman; Alexandre H. Kajita; Sameer Desale; Viana Azizi; Gebremedhin Melaku; Anh Bui; Yael F. Meirovich; Solomon Beyene; Aaphtaab Dheendsa; Blaine Schneider; Ron Waksman
• Keywords: Lumen (anatomy); Intravascular Ultrasound; Atherectomy

The CliRpath Excimer Laser System to Enlarge Lumen Openings (CELLO) registry included patients treated with modified excimer laser catheters for the endovascular treatment of peripheral artery disease affecting superficial femoral (SFA) and proximal popliteal artery. aim this study was assess, via intravascular ultrasound (IVUS) dissections in vessel wall following catheters. IVUS grayscale images from CELLO were systematically reviewed segments by two investigators. Images 33 patients; 66 pullbacks (1867 frames 2 phases), successfully matched frame-to-frame evaluate identical vessels phases; post-2 mm Turbo-Elite pilot channel creation post Turbo-Booster atherectomy. Dissections categorized as; (1) intimal, (2) medial, (3) intramural hematoma, (4) adventitial according ACC Clinical Expert Consensus Document classification dissections. An average 57 evaluated per pullback, giving a total 3734 pre-ablation (post creation) post-ablation phases). Treatments resulted significant increase lumen area 5.5 ± 3.2-mm2 (95% CI 4.3-6.8, p < 0.0001) reduction plaque plus media volume -10.6 36.0 mm3 -25.8 4.6, = 0.1619) whilst rise mainly hematoma formations 55% assessed 24% medial less than 1% disruption. based lesions debulking increased diameter negligible degree layer injury.