Transesophageal echocardiography in swine: evaluation of left and right ventricular structure, function and myocardial work

• DOI: 10.1007/s10554-020-02053-7
• Publication Date: 2020-10-13T06:02:47Z
• Authors: Sebastian Billig; Rashad Zayat; Andreas Ebeling; Henning Steffen; Christoph Nix; Nima Hatam; Heike Schnöring; Matthias Derwall
• Keywords: Original Paper; Heart Ventricles; Hemodynamic Monitoring; Sus scrofa; Hemodynamics; Reproducibility of Results; Myocardial Contraction; Echocardiography, Doppler; Ventricular Function, Left; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Heart Ventricles/diagnostic imaging [MeSH] ; Female [MeSH] ; Speckle tracking ; Ventricular Function, Left [MeSH] ; Myocardial Contraction [MeSH] ; Non-invasive hemodynamic monitoring ; Predictive Value of Tests [MeSH] ; Sus scrofa [MeSH] ; Ventricular Function, Right [MeSH] ; Myocardial contractility ; Animals [MeSH] ; Feasibility Studies [MeSH] ; Echocardiography, Doppler [MeSH] ; Models, Animal [MeSH] ; Swine model ; Reproducibility of Results [MeSH] ; Hemodynamic Monitoring [MeSH] ; Original Paper ; Hemodynamics [MeSH] ; Echocardiography, Transesophageal [MeSH] ; Transesophageal echocardiography ; Myocardial work; Models, Animal; Ventricular Function, Right; Animals; Feasibility Studies; Female; Echocardiography, Transesophageal

AbstractThis study aimed to determine standard left (LV) and right ventricular (RV) transesophageal echocardiographic (TEE) measurements in swine. Additionally, global myocardial work index (GWI) was estimated using pressure-strain loops (PSL). A comprehensive TEE examination was conducted in ten anesthetized, intubated and mechanically ventilated healthy female German landrace swine, weighing 44 to 57 kg. For GWI calculation, we performed LV and RV segmental strain analysis and used invasively measured LV and RV pressure to obtain PSL. The GWI and further myocardial work indices were calculated from the area of the PSL using commercially available software. Furthermore, hemodynamic measurements were obtained using indwelling catheters. We obtained complete standardized baseline values for left and right ventricular dimensions and function. Biplane LV ejection fraction was 63 ± 7 % and the LV end-diastolic volume was 70.5 ± 5.9 ml. Tissue Doppler estimated peak tricuspid annular systolic velocity was 13.1 ± 1.8 cm/s. The Doppler estimated LV and RV stroke volume index were 75.6 ± 7.2 ml/m2 and 76.7 ± 7.8 ml/m2 respectively. Pulsed wave Doppler derived cardiac output correlated well with cardiac output estimated using the thermodilution method (7.0 ± 1.2 l/min vs. 7.0 ± 1.1 l/min, r = 0.812, p = 0.004). The LV global longitudinal strain was -21.3 ± 3.9 % and the RV global longitudinal strain was -15.4 ± 2.5 %. LV GWI was 1885(1281–2121) mmHg*% and 297 ± 62 mmHg*% for the RV. LV global myocardial work efficiency was 82.6 ± 4 % and 83(72–88) % for the RV. TEE offers sufficient morphological, functional and hemodynamic assessment of the heart in swine. Myocardial contractility and mechanics can be reliably evaluated with the non-invasive GWI derived from echocardiography without additional invasive measures.