Coronary artery calcification and epicardial adipose tissue as independent predictors of mortality in COVID-19

• DOI: 10.1007/s10554-021-02276-2
• Publication Date: 2021-05-12T07:08:02Z
• Authors: Leandro Slipczuk; Francesco Castagna; Alison Schonberger; Eitan Novogrodsky; Richard Sekerak; Damini Dey; Ulrich P. Jorde; Jeffrey M. Levsky; Mario J. Garcia
• Keywords: Original Paper; SARS-CoV-2; COVID-19; Coronary Artery Disease; Coronary Vessels; 3. Good health; 03 medical and health sciences; COVID-19 Testing; 0302 clinical medicine; Adipose Tissue; Predictive Value of Tests; Risk Factors; Humans; Vascular Calcification; Pericardium; Retrospective Studies

Recent epidemiological studies have demonstrated that common cardiovascular risk factors are strongly associated with adverse outcomes in COVID-19. Coronary artery calcium (CAC) and epicardial fat (EAT) shown to outperform traditional predicting events the general population. We aim determine if CAC EAT determined by Computed Tomographic (CT) scanning can predict all-cause mortality patients admitted COVID-19 disease. performed a retrospective, post-hoc analysis of all Montefiore Medical Center confirmed diagnosis from March 1st, 2020 May 2nd, who had non-contrast CT chest within 5 years prior admission. ordinal scores quantified thoracic (TAT) volume examined their relationship inpatient mortality. A total 493 were analyzed. There 197 deaths (39.95%). Patients died during index admission higher age (72, [64-80] vs 68, [57-76]; p < 0.001), score (3, [0-6] 1, [0-4]; 0.001) (107, [70-152] 94, [64-129]; = 0.023). On competing regression model, ≥ 4 median (98 ml) independent predictors increased 63% (p 0.003) 43% 0.032), respectively. As composite, group combination 98 ml highest measured strong this high-risk cohort.