Elevated levels of sIL-2R, TNF-α and hs-CRP are independent risk factors for post percutaneous coronary intervention coronary slow flow in patients with non-ST segment elevation acute coronary syndrome

• DOI: 10.1007/s10554-022-02529-8
• Publication Date: 2022-02-19T14:04:26Z
• Authors: Cheng Wang; Yan Wu; Yang Su; Bin Mao; Yihong Luo; Yexiang Yan; Kun Hu; Yi Lu; Wenliang Che; Minying Wan
• Keywords: Original Paper; 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Abstract To evaluate the association between circulating levels of inflammatory cytokines and occurrence post-percutaneous coronary intervention (PCI) slow flow (CSF) in patients with non-ST segment elevation acute syndrome (NSTE-ACS). CSF after PCI commonly occurs implies poor outcomes, while determinants post-PCI NSTE-ACS remain controversial. In this multicenter case control study, 176 diagnosed occurred composed group, 352 matched group. Corrected thrombolysis myocardial infarction frame count (cTFC), related parameters were analyzed using Logistic regression models. Among 528 median age 67 (59–76) male proportion 65.5%, (35.0%) had defined as cTFC ≥ 24. Patients presented more intense activity revealed by higher white blood cell, high-sensitivity C-reactive protein (hs-CRP), interleukin-1ß (IL-1ß), soluble IL-2 receptor (sIL-2R), IL-6, IL-8, IL-10 tumor necrosis factor-α (TNF-α), comparable. Correlation analysis showed was positively correlated those cytokines. model indicates that hs-CRP (odds ratio (OR) = 3.038, 95% confidence interval (CI) 1.545–5.975), sIL-2R (OR 2.103, CI 1.959–4.026) TNF-α 3.708, 1.426–9.641) valuable predictors for occurrence. Elevated cytokine including hs-CRP, rather than could predict NSTE-ACS.