Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study From DA VINCI

• DOI: 10.1007/s10557-022-07343-x
• Publication Date: 2022-05-14T05:06:41Z
• Authors: Antonio J. Vallej...; Sarah Bray; Guillermo Villa; Julia Brandts; Gaia Kiru; Jennifer Murphy; Maciej Banach; Stefano De Servi; Dan Gaita; Ioanna Gouni-Bert...; G. Kees Hovingh; Jacek J. Jozwiak; J. Wouter Jukema; Robert Gabor Kiss; Serge Kownator; Helle K. Iversen; Vincent Maher; Luis Masana; Alexander Parkhom...; André Peeters; Piers Clifford; Katarina Raslova; Peter Siostrzonek; Stefano Romeo; Dimitrios Tousoulis; Charalambos Vlach...; Michal Vrablik; Alberico L. Catapano; Neil R. Poulter; Kausik K. Ray
• Keywords: Interquartile range; Atherosclerotic cardiovascular disease; Residual risk

Low-density lipoprotein cholesterol (LDL-C) recommendations differ between the 2018 American College of Cardiology/American Heart Association (ACC/AHA) and 2019 European Society Cardiology/European Atherosclerosis (ESC/EAS) guidelines for patients with atherosclerotic cardiovascular disease (ASCVD) (< 70 vs. < 55 mg/dl, respectively). In DA VINCI study, residual risk was predicted in ASCVD patients. The extent to which relative absolute might be lowered by achieving ACC/AHA versus ESC/EAS LDL-C recommended approaches simulated.DA a cross-sectional observational study prescribed lipid-lowering therapy (LLT) across 18 countries. Ten-year (CVR) among receiving stabilized LLT. For ≥ reduction required achieve an or mg/dl (LDL-C 69 54 respectively) calculated. Relative reductions (RRRs ARRs) were simulated.Of 2039 patients, 61% did not mg/dl. median (interquartile range) baseline 10-year CVR 93 (81-115) 32% (25-43%), respectively. Median 24 (12-46) 39 (27-91) needed Attaining goals resulted simulated RRRs 14% (7-25%) 22% (15-32%), respectively, ARRs 4% (2-7%) 6% (4-9%), respectively.In could result 2% additional ARR over 10 years approach.