Effect of Remote Ischaemic Conditioning on the Inflammatory Cytokine Cascade of COVID-19 (RIC in COVID-19): a Randomized Controlled Trial

• DOI: 10.1007/s10557-022-07411-2
• Publication Date: 2022-11-29T10:02:57Z
• Authors: Kishal Lukhna; Helison R. P. do ...; Alejandro Rossell...; Sean M. Davidson; Hayli Geffen; Sara Giesz; Pelin Golforoush; Ticiane Gonçalez ...; Diana Gorag; Alan Salama; Aqeela Imamdin; Siavash Kalkhoran; Sandrine Lecour; Mauricio W. Perroud; Mpiko Ntsekhe; Andrei C. Sposito; Derek M. Yellon
• Keywords: Cytokine Storm; Clinical endpoint

Patients hospitalized with COVID-19 may develop a hyperinflammatory, dysregulated cytokine "storm" that rapidly progresses to acute respiratory distress syndrome, multiple organ dysfunction, and even death. Remote ischaemic conditioning (RIC) has elicited anti-inflammatory cytoprotective benefits by reducing cytokines following sepsis in animal studies. Therefore, we investigated whether RIC would mitigate the inflammatory cascade induced COVID-19.