Neural stem cells in the ischemic and injured brain: endogenous and transplanted

• DOI: 10.1007/s10561-011-9283-z
• Publication Date: 2011-12-20T11:40:50Z
• Authors: Jing Dong; Baohua Liu; Lei Song; Lei Lu; Haitao Xu; Yue Gu
• Keywords: Brain Function; Brain ischemia

Neural stem cells functions as the pool of new neurons in adult brain, and plays important roles in normal brain function. Additionally, this pool reacts to brain ischemia, hemorrhage, trauma and many kinds of diseases, serving as endogenous repair mechanisms. The present manuscript discussed the responses of adult neurogenesis to brain ischemia and other insults, then the potential of neural stem cell transplantation therapy to treat such brain injury conditions.