Asymmetric Biginelli Reaction Catalyzed by Silicon, Titanium and Aluminum Oxides

• DOI: 10.1007/s10562-015-1666-5
• Publication Date: 2015-12-31T06:37:45Z
• Authors: Olga V. Fedorova; Yulia A. Titova; Alexey Yu. Vigorov; Maria S. Toporova; Olga A. Alisienok; Anna N. Murashkevich; Victor P. Krasnov; Gennady L. Rusinov; Valery N. Charushin
• Keywords: 01 natural sciences; 0104 chemical sciences

The asymmetric Biginelli reaction was investigated in the presence of N-[(2S,4R)-4-hydroxyprolyl]-(S)-1-phenylethylamine as chiral inducer and silicon, titanium or aluminum oxides (individual and mixed, bulk and nanosized) as heterogeneous catalysts. It has been shown that all studied oxides improve chemo- and stereoselectivity of the Biginelli reaction.